Yazar "Atılgan, Canan" için listeleme
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FbpA iron storage and release are governed by periplasmic microenvironments
Şensoy, Özge; Atılgan, Ali Rana; Atılgan, Canan (Royal Society of Chemistry, 2017)Ferric binding protein (FbpA) is part of an elaborate iron piracy mechanism evolved in Gram-negative bacteria, shuttling iron in the periplasmic space, from the outer to the cytoplasmic membrane side. We address how the ... -
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
İlter, Metehan; Kaşmer, Ramazan; Jalalypour, Farzaneh; Atılgan, Canan; Topçu, Ozan; Karakaş, Nihal; Şensoy, Özge (NLM (Medline), 2022)Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational ... -
Perturb-Scan-Pull: A novel method facilitating conformational transitions in proteins
Jalalypour, Farzaneh; Şensoy, Özge; Atılgan, Canan (American Chemical Society, 2020)Conformational transitions in proteins facilitate precise physiological functions. Therefor; it is crucial to understand the mechanisms underlying these processes to modulate protein function. Yet, studying structural and ... -
Perturbation-response scanning reveals key residues for allosteric control in Hsp70
Penkler, David; Şensoy, Özge; Atılgan, Canan; Taştan Bishop, Özlem (American Chemical Society, 2017)Hsp70 molecular chaperones play-an important role in maintaining-cellular homeostasis, and are implicated in a wide array of cellular processes, including protein recovery from aggregates, cross-membrane protein translocation, ... -
Soft segment length controls morphology of poly(ethylene oxide) based segmented poly(urethane-urea) copolymers in a binary solvent
Avaz, Senem; Oğuz, Oğuzhan; Kurt, Hasan; Menceloğlu, Yusuf Ziya; Atılgan, Canan (Elsevier Science Bv., 2017)It is known that morphology and structure-property behavior of poly(ethylene oxide) (PEO) based poly (urethane-urea) copolymers are affected by soft segment (SS) chain length. Here, a multi-scale computational study is ...